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Article

Inherited PTEN mutations and the prediction of phenotype.

Seminars in cell & developmental biology - 1 Apr 2016

Leslie Nicholas R, Longy Michel

Abstract excerpt

PTEN has been heavily studied due to its role as a tumour suppressor and as a core inhibitory component of the phosphoinositide 3-kinase (PI3K) signalling network. It is a broadly expressed phosphatase which displays complexity and diversity in both its functions and regulation and accordingly, in the laboratory numerous classes of functionally distinct mutations have been generated. Inherited loss of function...

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Source

Identifiers

PMID: 26827793
DOI: 10.1016/j.semcdb.2016.01.030

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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