Article
Novel 3'Rhesus box sequences confound RHD zygosity assignment.
Transfusion - 1 May 2002
Matheson Kimberly A, Denomme Gregory A
Abstract excerpt
BACKGROUND: Paternal RHD zygosity is required for genetic counseling and management of HDN caused by anti-D. The most common D- haplotype is due to the deletion of RHD, which results in the formation of a hybrid Rhesus box, theoretically through the recombination of 5' and 3'Rhesus boxes. STUDY DESIGN AND METHODS: The validity of Rhesus box PstI analysis was assessed to determine RHD zygosity by correlating D...
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