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Article

Functional promiscuity of squirrel monkey growth hormone receptor toward both primate and nonprimate growth hormones.

Molecular biology and evolution - 1 Jul 2002

Yi Soojin, Bernat Bryan, Pál Gábor, Kossiakoff Anthony, Li Wen-Hsiung

Abstract excerpt

Primate growth hormone (GH) has evolved rapidly, having undergone approximately 30% amino acid substitutions from the inferred ancestral eutherian sequence. Nevertheless, human growth hormone (hGH) is physiologically effective when administered to nonprimate mammals. In contrast, its functional counterpart, the human growth hormone receptor (hGHR), has evolved species specificity so that it responds only to Old...

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Source

Identifiers

PMID: 12082127
DOI: 10.1093/oxfordjournals.molbev.a004166

Genes

GHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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