Article
Episodic evolution of growth hormone in primates and emergence of the species specificity of human growth hormone receptor.
Molecular biology and evolution - 1 Jun 2001
Liu J C, Makova K D, Adkins R M, Gibson S, Li W H
Abstract excerpt
Growth hormone (GH) evolution is very conservative among mammals, except for primates and ruminant artiodactyls. In fact, most known mammalian GH sequences differ from the inferred ancestral mammalian sequence by only a few amino acids. In contrast, the human GH sequence differs from the inferred ancestral sequence by 59 amino acids. However, it is not known when this rapid evolution of GH occurred during primate...
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