Article
Segregation analysis of HDL cholesterol in the NHLBI Family Heart Study and in Utah pedigrees.
European journal of human genetics : EJHG - 1 Jun 2002
Kronenberg Florian, Coon Hilary, Ellison R Curtis, Borecki Ingrid, Arnett Donna K, Province Michael A, Eckfeldt John H, Hopkins Paul N, Hunt Steven C
Abstract excerpt
We investigated the genetic determination of high-density-lipoprotein cholesterol (HDL-C) levels in the NHLBI Family Heart Study by segregation analysis. Included was a total of 3755 subjects from 560 randomly selected nuclear families and 522 families selected due to a high family risk of coronary heart disease (CHD). In the whole dataset, there was no evidence for an allele at a major gene locus responsible for...
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