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Article

Decreased thermodynamic stability as a crucial factor for familial amyloidotic polyneuropathy.

Journal of molecular biology - 5 Jul 2002

Niraula Tara Nath, Haraoka Katsuki, Ando Yukio, Li Hua, Yamada Hiroaki, Akasaka Kazuyuki

Abstract excerpt

A single mutation in the wild-type transthyretin (WT TTR) such as V30M causes a familial amyloidotic polyneuropathy disease. Comparison of the three-dimensional crystal structures of WT and V30M does not tell much about the reason. High-pressure NMR revealed that at neutral pH both WT and V30M exist as equilibrium between the native tetramer and the dissociated/unfolded monomer. The native tetramer is highly...

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Share to Amyloid Neuropathies, Familial
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12079390
DOI: 10.1016/S0022-2836(02)00425-4

Genes

TTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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