Article
Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 2002
Winter Andreas, Krämer Wolfgang, Werner Fabian A O, Kollers Sonja, Kata Srinivas, Durstewitz Gregor, Buitkamp Johannes, Womack James E, Thaller Georg, Fries Ruedi
Abstract excerpt
DGAT1 encodes diacylglycerol O-acyltransferase (EC ), a microsomal enzyme that catalyzes the final step of triglyceride synthesis. It became a functional candidate gene for lactation traits after studies indicated that mice lacking both copies of DGAT1 are completely devoid of milk secretion, most likely because of deficient triglyceride synthesis in the mammary gland. Our mapping studies placed DGAT1 close to...
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