Article
Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition.
Genome research - 1 Feb 2002
Grisart Bernard, Coppieters Wouter, Farnir Frédéric, Karim Latifa, Ford Christine, Berzi Paulette, Cambisano Nadine, Mni Myriam, Reid Suzanne, Simon Patricia, Spelman Richard, Georges Michel, Snell Russell
Abstract excerpt
We recently mapped a quantitative trait locus (QTL) with a major effect on milk composition--particularly fat content--to the centromeric end of bovine chromosome 14. We subsequently exploited linkage disequilibrium to refine the map position of this QTL to a 3-cM chromosome interval bounded by microsatellite markers BULGE13 and BULGE09. We herein report the positional candidate cloning of this QTL, involving (1)...
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