Article
Adenovirus inhibition by peptidomimetic integrin antagonists.
Antiviral research - 1 Jul 2002
Hippenmeyer Paul J, Ruminski Peter G, Rico Joseph G, Lu H S Sharon, Griggs David W
Abstract excerpt
Many viruses and bacterial pathogens are capable of exploiting host cell surface integrins during their replication cycles. The ligands for many integrins contain an arginine-glycine-aspartic acid (RGD) amino acid sequence that is essential for protein-protein interaction. Human adenovirus particles contain this sequence in the penton base protein, and previous studies support a role for this RGD in...
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