Article
Effects of platelet membrane glycoprotein polymorphisms on the risk of myocardial infarction in young males.
The Israel Medical Association journal : IMAJ - 1 Jun 2002
Rosenberg Nurit, Zivelin Ariella, Chetrit Angela, Dardik Rima, Kornbrot Nurit, Freimark Dov, Inbal Aida
Abstract excerpt
BACKGROUND: Platelet adhesion and aggregation are mediated by specific platelet membrane glycoproteins GPla/IIa, GPlb alpha, and GPIIb/IIIa, and are essential steps in thrombus formation and development of acute myocardial infarction. OBJECTIVE: To evaluate the risks exerted by each of the following polymorphisms in young males with AMI: HPA-1a/b in GPIIIa: 807C/T in GPIa; and HPA-2a/b. VNTR and Kozak C/T in GPlb...
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