Article
Parkinson's disease: one biochemical pathway to fit all genes?
Trends in molecular medicine - 1 May 2002
Krüger Rejko, Eberhardt Olaf, Riess Olaf, Schulz Jörg B
Abstract excerpt
Although originally discounted, hereditary factors have emerged as the focus of research in Parkinson's disease (PD). Genetic studies have identified mutations in alpha-synuclein and ubiquitin C-terminal hydrolase as rare causes of autosomal dominant PD and mutations in parkin as a cause of autosomal recessive PD. Functional characterization of the identified disease genes implicates the ubiquitin-mediated...
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