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Article

Reduced activation of inflammatory responses in host cells by mouse-adapted Helicobacter pylori isolates

1 May 2002

Abstract excerpt

Helicobacter pylori strains that harbour the Cag pathogenicity island (Cag PAI) induce interleukin (IL)-8 secretion in gastric epithelial cells, via the activation of NF- kappa B, and are associated with severe inflammation in humans. To investigate the influence of Cag PAI-mediated inflammatory responses on H. pylori adaptation to mice, a selection of H. pylori clinical isolates (n = 12) was cag PAI genotyped...

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PMID: 12064285
DOI: 10.1046/j.1462-5822.2002.00189.x

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