Article
Differential effect of PPARgamma2 variants in the development of type 2 diabetes between native Japanese and Japanese Americans.
Diabetes research and clinical practice - 1 Aug 2002
Nemoto Masami, Sasaki Takashi, Deeb Samir S, Fujimoto Wilfred Y, Tajima Naoko
Abstract excerpt
Common type 2 diabetes mellitus is a disorder that is though to develop by interaction between genetic and environmental factors. Among these factors, peroxisome proliferator-activated receptor (PPAR)gamma gene was identified as a genetic element which variant form, Pro12Ala, was shown to have differential metabolic activity than the wild type. To elucidate the mechanism of interaction between genetic and...
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