Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetics of leptin and obesity: a HuGE review.

American journal of epidemiology - 15 Jul 2005

Paracchini Valentina, Pedotti Paola, Taioli Emanuela

Abstract excerpt

Leptin is an important regulator of the mass of adipose tissue and of body weight; it operates by inhibiting food intake and stimulating energy expenditure. Some polymorphic genes involved in the regulation of leptin-the leptin gene (LEP A19G), the leptin receptor gene (LEPR Q223R, K109R, and K656N), and the peroxisome proliferator-activated receptor-gamma gene (PPARG P12A and C161T)--have been investigated as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Weights and Measures
Share to Genetics, Population
Share to Leptin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Obesity

Share to PPAR gamma

Share to Racial Groups

Share to Receptors, Cell Surface

Share to Receptors, Leptin

Source

Identifiers

PMID: 15972940
DOI: 10.1093/aje/kwi174

Genes

LEP
LEPR
PPARG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetics of leptin and obesity: a HuGE review.PMID 15972940Read ↗

A study of leptin and its gene 2548 G/A Rs7799039 single-nucleotide polymorphisms in Egyptian children: A single-center experience.Semantic proximity Read ↗

Leptin: Genes, Concepts and Clinical PerspectiveSemantic proximity Read ↗

Genetic Association of LEP Gene Polymorphisms with Obesity in Moroccan Individuals: Case-Control Study and Updated Meta-analysis.Semantic proximity Read ↗

Relationship Between Leptin G2548A and Leptin Receptor Q223R Gene Polymorphisms and Obesity and Metabolic Syndrome Risk in Tunisian VolunteersSemantic proximity Read ↗

Genetic variants in leptin: Determinants of obesity and leptin levels in South Indian populationSemantic proximity Read ↗

[Association of leptin gene-2548 G/A polymorphism with obesity: a meta-analysis].Semantic proximity Read ↗

Genetic, molecular and physiological insights into human obesity.Semantic proximity Read ↗

LEP -2548G>A Polymorphism of the Leptin Gene and Its Influence on the Lipid Profile in Obese Individuals.Semantic proximity Read ↗

Leptin and Leptin receptor polymorphisms, plasma Leptin levels and obesity in Tunisian volunteers.Semantic proximity Read ↗

Genetic polymorphisms in adipokine genes and the risk of obesity: a systematic review and meta-analysis.Semantic proximity Read ↗

Lack of association between leptin G-2548A polymorphisms and obesity risk: Evidence based on a meta-analysis.Semantic proximity Read ↗

Association with leptin gene C.-2548 G>A polymorphism, serum leptin levels, and body mass index in Turkish obese patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.