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Article

Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA.

Genes & development - 1 Jun 2002

Ivessa Andreas S, Zhou Jin-Qiu, Schulz Vince P, Monson Ellen K, Zakian Virginia A

Abstract excerpt

In wild-type Saccharomyces cerevisiae, replication forks slowed during their passage through telomeric C(1-3)A/TG(1-3) tracts. This slowing was greatly exacerbated in the absence of RRM3, shown here to encode a 5' to 3' DNA helicase. Rrm3p-dependent fork progression was seen at a modified Chromosome VII-L telomere, at the natural X-bearing Chromosome III-L telomere, and at Y'-bearing telomeres. Loss of Rrm3p also...

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Identifiers

PMID: 12050116
DOI: 10.1101/gad.982902
PMCID: PMC186315

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Source receipt: pubmed, retrieved 7 Sept 2026.

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