Article
Intra-individual variation and sex differences in gene expression of cytochromes P450 in circulating leukocytes.
The pharmacogenomics journal - 1 Jan 2002
Finnström N, Ask B, Dahl M-L, Gadd M, Rane A
Abstract excerpt
To clarify partly inconsistent results in gene expression of cytochromes P450 (CYP) in the circulation, we undertook a systematic study over a long time period in 19 healthy men and women. CYP specific mRNA for 1A2, 1B1, 2E1 and 3A4 was studied in the leukocytes collected repeatedly on 20 occasions over a 10-week period. Our study revealed a varying pattern of CYP expression over time. CYP3A4 specific mRNA...
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