Article
Aluminium in Alzheimer's disease: are we still at a crossroad?
Cellular and molecular life sciences : CMLS - 1 Jan 2005
Gupta Veer Bala, Anitha S, Hegde M L, Zecca L, Garruto R M, Ravid R, Shankar S K, Stein R, Shanmugavelu P, Jagannatha Rao K S
Abstract excerpt
Aluminium, an environmentally abundant non-redox trivalent cation has long been implicated in the pathogenesis of Alzheimer's disease (AD). However, the definite mechanism of aluminium toxicity in AD is not known. Evidence suggests that trace metal homeostasis plays a crucial role in the normal functioning of the brain, and any disturbance in it can exacerbate events associated with AD. The present paper reviews...
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