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Article

Exaggerated apoptosis and NF-kappaB activation in pancreatic and tracheal cystic fibrosis cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2007

Rottner Mathilde, Kunzelmann Corinne, Mergey Martine, Freyssinet Jean-Marie, Martínez María Carmen

Abstract excerpt

The pathophysiologic mechanisms causing inflammation in cystic fibrosis (CF) remain obscure. The effects of proapoptotic agents on pancreatic and tracheal cell lines expressing wild-type CFTR (PANC-1 and NT-1, respectively) or the homozygous CFTRDeltaF508 mutation (CFPAC-1 and CFT-2, respectively) were assessed. An increased susceptibility to apoptosis was observed in CFPAC-1 and CFT-2 cells. Apoptosis was...

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Identifiers

PMID: 17442732
DOI: 10.1096/fj.06-7614com

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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