Article
Bovine papillomavirus type 1 E6-induced sensitization to apoptosis is distinct from its transforming activity.
Virology - 10 Apr 2002
Liu Zhiguo, Liu Yun, Hong Yihui, Rapp Lisa, Androphy Elliot J, Chen Jason J
Abstract excerpt
The bovine papillomavirus type 1 (BPV-1) E6 oncoprotein induces tumorigenic transformation of murine C127 cells and stimulates transcription when targeted to a promoter. We have previously shown that C127 cells expressing BPV-1 E6 exhibited increased tumor necrosis factor alpha (TNF)-mediated apoptosis. To understand the mechanisms by which BPV-1 E6 sensitizes cells to apoptosis and to investigate the relevance...
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