Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequence analysis of the pro-opiomelanocortin (POMC) gene in obese/diabetic Japanese.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 May 2002

Ohshiro Y, Ueda K, Wakasaki H, Kosaka M, Nishi M, Sasaki H, Takasu N, Nanjo K

Abstract excerpt

Pro-opiomelanocortin (POMC)-derived peptides play a critical role in body weight regulation in the central nervous system. Mice deficient in POMC developed obesity. We sought mutations in the POMC gene in 50 morbidly obese (body mass index 35-60 kg/m(2)) Japanese subjects with diabetes by direct sequencing. Apart from two silent mutations (C6982T and C7285T), no other mutations were detected. Frequencies of these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Mass Index
Share to Diabetes Mellitus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to Obesity

Share to Obesity, Morbid

Share to Pro-Opiomelanocortin

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 12032760
DOI: 10.1038/sj.ijo.0801950

Genes

POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Sequence analysis of the pro-opiomelanocortin (POMC) gene in obese/diabetic Japanese.PMID 12032760Read ↗

Systematic mutation screening of the pro-opiomelanocortin gene: identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes.Semantic proximity Read ↗

A novel missense mutation in the signal peptide of the human POMC gene: a possible additional link between early-onset type 2 diabetes and obesitySemantic proximity Read ↗

Pro-opiomelanocortin (POMC) Deficiency and Peripheral Melanocortins in ObesitySemantic proximity Read ↗

Molecular scanning for mutations in the melanocortin-4 receptor gene in obese/diabetic Japanese.Semantic proximity Read ↗

A case of early-onset obesity, hypocortisolism, and skin pigmentation problem due to a novel homozygous mutation in the proopiomelanocortin (POMC) gene in an Indian boy.Semantic proximity Read ↗

[Screening of mutations in genes of pro-opiomelanocortin in patients with constitutional exogenous obesity].Semantic proximity Read ↗

Mutation in bombesin receptor subtype-3 gene is not a major cause of obesity in the Japanese.Semantic proximity Read ↗

Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity.Semantic proximity Read ↗

Molecular screening of both the promoter and the protein coding regions in the human ob gene in Japanese obese subjects with non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.