Article
Polymorphisms of the TGFBRAP1 gene in relation to blood pressure variability and plasma TGF-β1.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Jan 2015
Guo Daoxia, Shen Chong, Chen Yanchun, Yang Song, Wang Linhong, Jin Yuelong, He Lianping, Chen Jinfeng, Zhao Xianghai, Zhou Wei, Zhao Hailong, Yao Yingshui
Abstract excerpt
TGF-β receptor-associated protein 1 (TGFBRAP1), as a chaperone, binds Smad4 to participate in vascular development and remodeling which is closely related to the aetiology of essential hypertension (EH). Herein, the main aim of this study is to investigate the genetic susceptibility of TGFBRAP1 to hypertension. A case-control study comprising 2012 hypertension cases and 2210 controls was used to generate the...
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