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Article

A fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells in vivo

21 May 2002

Abstract excerpt

We used a screening procedure to identify protein domains from phage-displayed cDNA libraries that bind both to bone marrow endothelial progenitor cells and tumor vasculature. Screening phage for binding of progenitor cell-enriched bone marrow cells in vitro, and for homing to HL-60 human leukemia cell xenograft tumors in vivo, yielded a cDNA fragment that encodes an N-terminal fragment of human high mobility...

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PMID: 12032302
DOI: 10.1073/pnas.062189599

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