Article
HMGB1 Protein Binds to Influenza Virus Nucleoprotein and Promotes Viral Replication
14 Jun 2012
Abstract excerpt
Influenza virus has evolved replication strategies that hijack host cell pathways. To uncover interactions between viral macromolecules and host proteins, we applied a phage display strategy. A library of human cDNA expression products displayed on filamentous phages was submitted to affinity selection for influenza viral ribonucleoproteins (vRNPs). High-mobility-group box (HMGB) proteins were found to bind to...
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