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Article

DNA-dependent targeting of cell nuclei by a lupus autoantibody

9 Jul 2015

Abstract excerpt

A nuclear-penetrating lupus anti-DNA autoantibody, 3E10, has been found to inhibit DNA repair and selectively kill certain cancer cells that are highly vulnerable to DNA damage. In addition, a 3E10 single chain variable fragment (scFv) has been developed for use as a delivery vehicle to carry therapeutic cargo proteins into cell nuclei. A greater understanding of the mechanism by which 3E10 penetrates cell nuclei...

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PMID: 26156563
DOI: 10.1038/srep12022

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