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Article

The evolution of drug–resistant malaria: the role of drug elimination half–life

29 Apr 2002

Abstract excerpt

This paper seeks to define and quantify the influence of drug elimination half-life on the evolution of antimalarial drug resistance. There are assumed to be three general classes of susceptibility of the malaria parasite Plasmodium falciparum to a drug: Res0, the original, susceptible wildtype; Res1, a group of intermediate levels of susceptibility that are more tolerant of the drug but still cleared by...

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Identifiers

PMID: 12028788
DOI: 10.1098/rstb.2001.1036

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