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Article

Components of the SAGA histone acetyltransferase complex are required for repressed transcription of ARG1 in rich medium.

Molecular and cellular biology - 1 Jun 2002

Ricci Andrea R, Genereaux Julie, Brandl Christopher J

Abstract excerpt

Transcriptional regulation of the Saccharomyces cerevisiae ARG1 gene is controlled by positive and negative elements. The transactivator Gcn4p is required for activation in minimal medium, while arginine repression requires the ArgR/Mcm1 regulatory complex, which binds to two upstream arginine control elements. We have found that the coordinated regulation of ARG1 requires components of the SAGA...

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Identifiers

PMID: 12024017
DOI: 10.1128/MCB.22.12.4033-4042.2002
PMCID: PMC133849

Genes

ARG1
ADA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Components of the SAGA histone acetyltransferase complex are required for repressed transcription of ARG1 in rich medium.PMID 12024017Read ↗

The E2 ubiquitin conjugase Rad6 is required for the ArgR/Mcm1 repression of ARG1 transcription.Semantic proximity Read ↗

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Promoter regulation by distinct mechanisms of functional interplay between lysine acetylase Rtt109 and histone chaperone Asf1.Semantic proximity Read ↗

Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo.Semantic proximity Read ↗

Simultaneous recruitment of coactivators by Gcn4p stimulates multiple steps of transcription in vivo.Semantic proximity Read ↗

The Saccharomyces cerevisiae Srb8-Srb11 complex functions with the SAGA complex during Gal4-activated transcription.Semantic proximity Read ↗

Combinatorial regulation of the Saccharomyces cerevisiae CAR1 (arginase) promoter in response to multiple environmental signals.Semantic proximity Read ↗

ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3.Semantic proximity Read ↗

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