A role for XRCC2 gene polymorphisms in breast cancer risk and survival.

doi:10.1136/jmedgenet-2011-100018

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Article

A role for XRCC2 gene polymorphisms in breast cancer risk and survival.

Journal of medical genetics - 1 Jul 2011

Lin Wei-Yu, Camp Nicola J, Cannon-Albright Lisa A, Allen-Brady Kristina, Balasubramanian Sabapathy, Reed Malcolm W R, Hopper John L, Apicella Carmel, Giles Graham G, Southey Melissa C, Milne Roger L, Arias-Pérez Jose I, Menéndez-Rodríguez Primitiva, Benítez Javier, Grundmann Magdalena, Dubrowinskaja Natalia, Park-Simon Tjoung-Won, Dörk Thilo, Garcia-Closas Montserrat, Figueroa Jonine, Sherman Mark, Lissowska Jolanta, Easton Douglas F, Dunning Alison M, Rajaraman Preetha, Sigurdson Alice J, Doody Michele M, Linet Martha S, Pharoah Paul D, Schmidt Marjanka K, Cox Angela

Abstract excerpt

BACKGROUND: The XRCC2 gene is a key mediator in the homologous recombination repair of DNA double strand breaks. It is hypothesised that inherited variants in the XRCC2 gene might also affect susceptibility to, and survival from, breast cancer. METHODS: The study genotyped 12 XRCC2 tagging single nucleotide polymorphisms (SNPs) in 1131 breast cancer cases and 1148 controls from the Sheffield Breast Cancer Study...

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Identifiers

PMID: 21632523
DOI: 10.1136/jmedgenet-2011-100018
PMCID: PMC3932658

Genes

XRCC2
MAF

Variants

rs3218536

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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