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Article

Identification of a novel phosphatidic acid binding domain in protein phosphatase-1.

Biochemistry - 11 Oct 2005

Jones Jeffrey A, Rawles Robert, Hannun Yusuf A

Abstract excerpt

Phosphatidic acid (PA) has been recognized as a lipid second messenger, yet few cellular targets for PA have been identified. Previous work demonstrated PA as a potent and noncompetitive tight-binding inhibitor of the catalytic subunit (gamma isoform) of protein phosphatase-1 (PP1c gamma) in vitro. The high potency of inhibition, coupled with high specificity for PA over other phospholipids, suggested the...

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PMID: 16201749
DOI: 10.1021/bi0505159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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