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Article

Mefloquine and new related compounds target the F(0) complex of the F(0)F(1) H(+)-ATPase of Streptococcus pneumoniae.

Antimicrobial agents and chemotherapy - 1 Jun 2002

Martín-Galiano Antonio Javier, Gorgojo Begoña, Kunin Calvin M, de la Campa Adela G

Abstract excerpt

The activities of mefloquine (MFL) and related compounds against previously characterized Streptococcus pneumoniae strains carrying defined amino acid substitutions in the c subunit of the F(0)F(1) H(+)-ATPase were studied. In addition, a series of MFL-resistant (Mfl(r)) strains were isolated and characterized. A good correlation was observed between inhibition of growth and inhibition of the membrane-associated...

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Identifiers

PMID: 12019076
DOI: 10.1128/AAC.46.6.1680-1687.2002
PMCID: PMC127268

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Source receipt: pubmed, retrieved 7 Sept 2026.

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