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Article

High prevalence of polymorphisms of angiotensin-converting enzyme (I/D) and endothelial nitric oxide synthase (Glu298Asp) in patients with systemic sclerosis.

The American journal of medicine - 1 May 2002

Fatini Cinzia, Gensini Francesca, Sticchi Elena, Battaglini Beatrice, Angotti Chiara, Conforti Maria L, Generini Sergio, Pignone Alberto, Abbate Rosanna, Matucci-Cerinic Marco

Abstract excerpt

PURPOSE: Systemic sclerosis is characterized by progressive microvascular occlusion and fibrosis and by an imbalance in the fibrinolytic system. In vivo and in vitro studies suggest that the renin-angiotensin system partly regulates vascular fibrinolytic balance. Angiotensin II increases the production and secretion of plasminogen activator inhibitor-1, while angiotensin-converting enzyme (ACE) contributes to...

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Source

Identifiers

PMID: 12015245
DOI: 10.1016/s0002-9343(02)01069-0

Genes

ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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