Impact of eNOS 27-bp VNTR (4b/a) gene polymorphism with the risk of Systemic Lupus Erythematosus in south Indian subjects.

doi:10.1016/j.gene.2018.03.021

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Article

Impact of eNOS 27-bp VNTR (4b/a) gene polymorphism with the risk of Systemic Lupus Erythematosus in south Indian subjects.

Gene - 5 Jun 2018

Katkam Shiva Krishna, Indumathi Bobbala, Tasneem Fatima S D, Rajasekhar Liza, Kutala Vijay Kumar

Abstract excerpt

OBJECTIVE: Endothelial nitric oxide synthase (eNOS) is constitutively expressed by vascular endothelium including glomerular endothelium. Functional polymorphisms, -786T>C (rs2070744) promoter variant, 27 bp VNTR (4b/a) in intron 4 and 894G>T (rs1799983) exon variant of eNOS are known to alter the eNOS expression and activity leading to altered NO levels and contribute to the development of vascular and renal...

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PMID: 29524578
DOI: 10.1016/j.gene.2018.03.021

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