Article
Reversal of halophilicity in a protein-DNA interaction by limited mutation strategy.
Structure (London, England : 1993) - 1 May 2002
Bergqvist Simon, Williams Mark A, O'Brien Ronan, Ladbury John E
Abstract excerpt
Comparison of the genes of functionally homologous proteins in organisms existing in different environments shows that adaptation is most often accomplished by mutation of an existing protein. However, from such comparisons, the significance of individual residues to the particular environmental adaptation is not generally discernable among the mass of changes that occur over evolutionary time. This can be...
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