Article
Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases.
Proteins - 1 Jan 1990
Perry K M, Fauman E B, Finer-Moore J S, Montfort W R, Maley G F, Maley F, Stroud R M
Abstract excerpt
The structure of thymidylate synthase (TS) from Escherichia coli was solved from cubic crystals with a = 133 A grown under reducing conditions at pH 7.0, and refined to R = 22% at 2.1 A resolution. The structure is compared with that from Lactobacillus casei solved to R = 21% at 2.3 A resolution. The structures are compared using a difference distance matrix, which identifies a common core of residues that...
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