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Persistent HIV-1 infection of natural killer cells in patients receiving highly active antiretroviral therapy

14 May 2002

Abstract excerpt

We have identified a subset of CD56(+)CD3(-) human natural killer (NK) cells that express CD4 and the HIV coreceptors CCR5 and CXCR4. These cells can be productively infected in vitro by both CCR5- and CXCR4-using molecular clones of HIV-1 in a CD4-dependent manner. Analysis of HIV-infected persons showed that viral DNA is present in purified NK cells, and virus could be rescued from these cells after in vitro...

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PMID: 12011460
DOI: 10.1073/pnas.102672999

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