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Article

Topoisomerase IIalpha gene expression is regulated by the p53 tumor suppressor gene in nonsmall cell lung carcinoma patients.

Cancer - 15 Apr 2002

Liu Dage, Huang Cheng-long, Kameyama Kotaro, Hayashi Eiichi, Yamauchi Akira, Sumitomo Shinichi, Yokomise Hiroyasu

Abstract excerpt

BACKGROUND: Topoisomerase IIalpha (Topo IIalpha) is an essential nuclear enzyme for chromosome segregation during mitosis. Previous experimental studies using cell lines reported that Topo IIalpha expression was negatively regulated by wild-type p53 through the gene's promoter region. METHODS: Surgically resected tumor specimens from 98 nonsmall cell lung carcinoma (NSCLC) patients who were not treated with...

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Share to Antigens, Neoplasm
Share to Carcinoma, Large Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

Share to DNA Topoisomerases, Type II

Share to Gene Expression Regulation, Enzymologic

Share to Genes, Tumor Suppressor

Share to Polymorphism, Single-Stranded Conformational

Share to RNA, Neoplasm

Source

Identifiers

PMID: 12001123
DOI: 10.1002/cncr.10450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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