Article
Regulation of the collagen phenotype expression of gamma-irradiated vascular smooth muscle cells by heparan mimetics (RGTA).
Journal of biomedical materials research. Part A - 15 Sept 2004
Alexakis C, Strup C, Mestries P, Mathé D, Caruelle J P, Barritault D, Kern P
Abstract excerpt
Restenosis is characterized by vascular smooth muscle cell (VSMC) proliferation and accumulation of collagen III in a hypertrophic and disorganized extracellular matrix. Restenosis is prevented by antimitotic agents or irradiation but no significant progress has been made to control collagen expression deregulation. Previously, we have shown that a new family of biopolymers named RGTA (heparan mimetics elaborated...
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