Article
The Karlsburg type 1 diabetes risk study of a normal schoolchild population: association of beta-cell autoantibodies and human leukocyte antigen-DQB1 alleles in antibody-positive individuals.
The Journal of clinical endocrinology and metabolism - 1 May 2002
Schlosser Michael, Strebelow Martina, Wassmuth Ralf, Arnold Marie-Luise, Breunig Isabel, Rjasanowski Ilona, Ziegler Brigitte, Ziegler Manfred
Abstract excerpt
The intent of this study was to analyze the prevalence of diabetes-associated autoantibodies (AAbs) at or above the 99(th) percentile as well as their association with human leukocyte antigen (HLA)-DQB1 alleles in a normal population of 6,337 schoolchildren. AAbs against glutamic acid decarboxylase (GADA), tyrosine phosphatase IA-2 (IA-2A), and/or insulin (IAA) were detected by (125)I-antigen binding and islet...
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