Article
Multiple and high-titer single autoantibodies in schoolchildren reflecting the genetic predisposition for type 1 diabetes.
Annals of the New York Academy of Sciences - 1 Nov 2003
Schlosser Michael, Wassmuth Ralf, Strebelow Martina, Rjasanowski Ilona, Ziegler Manfred
Abstract excerpt
The study aimed to compare the HLA specificities of AAb-positive healthy schoolchildren with those of patients with type 1 diabetes (T1D). HLA-DRB1 and DQB1 alleles were determined in 178 AAb-positive and 339 AAb-negative schoolchildren aged 6-17 years without first-degree relatives with T1D and in 274 patients with T1D. AAbs against glutamic acid decarboxylase (GADA), protein tyrosine phosphatase (IA-2A), and...
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