Article
No missense mutation of WKL1 in a subgroup of probands with schizophrenia.
Molecular psychiatry - 1 Jan 2002
Devaney J M, Donarum E A, Brown K M, Meyer J, Stöber G, Lesch K P, Nestadt G, Stephan D A, Pulver A E
Abstract excerpt
Recently, a Leu309Met mutation in WKL1 (MLC1, KIAA0027), a gene mapped to chromosome 22q13.33, was reported to co-segregate with periodic catatonia, a clinical sub-type of schizophrenia, in seven members of an extended pedigree.(1) WKL1 encodes a putative membrane protein expressed exclusively in the brain, particularly in the amygdala, nucleus caudatus, thalamus, and hippocampus.(1) We screened WKL1 for...
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