Article
hKCNN3 which maps to chromosome 1q21 is not the causative gene in periodic catatonia, a familial subtype of schizophrenia.
European archives of psychiatry and clinical neuroscience - 1 Jan 2000
Stöber G, Meyer J, Nanda I, Wienker T F, Saar K, Jatzke S, Schmid M, Lesch K P, Beckmann H
Abstract excerpt
The human calcium-activated potassium channel gene (hKCNN3, hSKCa3) contains two tandemly arranged, multiallelic CAG repeats located in exon 1 which result in short to moderate polyglutamine stretches of unknown functional significance. Case-control and family-based association studies suggested an association of hKCNN3 repeats with susceptibility for schizophrenia. Twelve multiplex pedigrees with periodic...
Topics
- Adult
- Catatonia
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- Exons
- Female
- Gene Expression
- Genetic Linkage
- Genetic Markers
- Genetic Predisposition to Disease
- Humans
- In Situ Hybridization, Fluorescence
- Male