Lack of somatic hypermutation of IG V(H) genes in lymphoid malignancies with t(2;14)(p13;q32) translocation involving the BCL11A gene.

doi:10.1038/sj.leu.2402480

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Article

Lack of somatic hypermutation of IG V(H) genes in lymphoid malignancies with t(2;14)(p13;q32) translocation involving the BCL11A gene.

Leukemia - 1 May 2002

Küppers R, Sonoki T, Satterwhite E, Gesk S, Harder L, Oscier D G, Tucker P W, Dyer M J S, Siebert R

Abstract excerpt

The t(2;14)(p13;q32.3) involving the BCL11A and IGH genes is a rare but recurrent chromosomal aberration in B-cell malignancies. Hitherto, juxtaposition of BCL11A and IGH has only been described in B-cell chronic lymphocytic leukemia (B-CLL) and immunocytoma. As subgroups of B-CLL can be distinguished by the pattern of somatic mutation of immunoglobulin variable (V) genes we investigated four lymphomas with...

Topics

Carrier Proteins
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 2
Genes, Immunoglobulin
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Switch Region
Immunoglobulin Variable Region
Leukemia, Lymphocytic, Chronic, B-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoma, B-Cell

Mutation

Neoplasm Proteins

Nuclear Proteins

Repressor Proteins

Sequence Analysis, DNA

Translocation, Genetic

Source

Open in PubMed

Identifiers

PMID: 11986957
DOI: 10.1038/sj.leu.2402480

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