Article
A mouse with a point mutation in plasma membrane Ca2+-ATPase isoform 2 gene showed the reduced Ca2+ influx in cerebellar neurons.
Neuroscience research - 1 Apr 2002
Ueno Takeshi, Kameyama Kohzoh, Hirata Mihoko, Ogawa Miyuki, Hatsuse Hiromi, Takagaki Yohtaroh, Ohmura Michio, Osawa Nobutaka, Kudo Yoshihisa
Abstract excerpt
We analyzed mutant mice showing behavioral defects such as severe tremor, up-and-down and side-to-side wriggling of neck without coordination, and found that the gene causing the defects was located between 46 and 60.55 centimorgans (cM) on the mouse chromosome 6. In this region, nucleotide transition of the plasma membrane Ca2+-ATPase isoform 2 (PMCA2) gene was found, which caused a glutamic acid to change into...
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