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Article

Angiotensin II Inhibits Human Trophoblast Invasion through AT1 Receptor Activation

1 Jul 2002

Abstract excerpt

Trophoblast implantation depends, in part, on the controlled production of plasmin from plasminogen, a process regulated by plasminogen activators and plasminogen activator inhibitors. We have determined that angiotensin II (Ang II) stimulates plasminogen activator inhibitor-1 (PAI-1) synthesis and secretion in human trophoblasts in a time- and concentration-dependent manner. Our results indicate that Ang II...

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PMID: 11983698
DOI: 10.1074/jbc.m201369200

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