Article
A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes.
Diabetes - 1 May 2002
Awata Takuya, Inoue Kiyoaki, Kurihara Susumu, Ohkubo Tomoko, Watanabe Masaki, Inukai Kouichi, Inoue Ikuo, Katayama Shigehiro
Abstract excerpt
Vascular endothelial growth factor (VEGF), a major mediator of vascular permeability and angiogenesis, may play a pivotal role in mediating the development and progression of diabetic retinopathy. In the present study, we examined the genetic variations of the VEGF gene to assess its possible relation to diabetic retinopathy in type 2 diabetic patients. Among seven common polymorphisms in the promoter region,...
Topics
- 5' Untranslated Regions
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Diabetes Mellitus, Type 2
- Diabetic Retinopathy
- Endothelial Growth Factors
- Female
- Genotype
- Humans
- Linkage Disequilibrium
- Lymphokines