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Article

A novel disintegrin domain protein affects early cell type specification and pattern formation in Dictyostelium.

Development (Cambridge, England) - 1 May 2002

Varney Timothy R, Ho Hoa, Petty Chere', Blumberg Daphne D

Abstract excerpt

The cellular slime mold, Dictyostelium discoideum is a non-metazoan organism, yet we now demonstrate that a disintegrin domain-containing protein, the product of the ampA gene, plays a role in cell type specification. Disintegrin domain-containing proteins are involved in Notch signaling in Drosophila and C. elegans via an ectodomain shedding mechanism that depends on a metalloprotease domain. The Dictyostelium...

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Identifiers

PMID: 11973270
DOI: 10.1242/dev.129.10.2381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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