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Translocations of 14q32 and deletions of 13q14 are common chromosomal abnormalities in systemic amyloidosis

25 Apr 2002

Abstract excerpt

Systemic monoclonal immunoglobulin light chain amyloidosis (AL) is associated with clonal plasma cell dyscrasias that are often subtle and non-proliferating. AL shares numerical chromosomal changes with multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS). Illegitimate translocations involving the immunoglobulin heavy chain gene (IGH) at 14q32 and deletions of the long arm of...

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Share to Amyloidosis: Diagnosis, Treatment, Outcomes
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PMID: 11972529
DOI: 10.1046/j.1365-2141.2002.03438.x

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