Article

Retinal Function Deficits in American Staffordshire Terriers with a Late-Onset Neurodegenerative Disease Associated with an <em>ARSG</em> Variant

2025-08-11

Abstract excerpt

American Staffordshire Terriers (AST) with a c.296G>A variant in ARSG develop progres-sive ataxia, cerebellar atrophy, and neuronal accumulation of autofluorescent storage ma-terial. Human subjects with ARSG variants exhibit hearing loss and rod-cone dystrophy without apparent neurological involvement and arsg knock-out mice exhibit progressive ataxia, lysosomal storage and photoreceptor loss. A study was under...

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Literature Corpus work: 08e0c2e7-1e4c-5b63-98e5-578ae83bd97d
DOI: 10.20944/preprints202508.0680.v1

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Retinal Function Deficits in American Staffordshire Terriers with a Late-Onset Neurodegenerative Disease Associated with an <em>ARSG</em> VariantDOI 10.20944/preprints202508.0680.v1Read

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