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Article

Altered sexual and social behaviors in trp2 mutant mice.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2002

Leypold Bradley G, Yu C Ron, Leinders-Zufall Trese, Kim Michelle M, Zufall Frank, Axel Richard

Abstract excerpt

We have used gene targeting to generate mice with a homozygous deficiency in trp2, a cation channel expressed in the vomeronasal organ (VNO). Trp2 mutant animals reveal a striking reduction in the electrophysiological response to pheromones in the VNO, suggesting that trp2 plays a central role in mediating the pheromone response. These mutants therefore afford the opportunity to examine the role of the VNO in the...

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Identifiers

PMID: 11972034
DOI: 10.1073/pnas.082127599
PMCID: PMC122956

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Source receipt: pubmed, retrieved 7 Sept 2026.

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