Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Relaxed selective pressure on an essential component of pheromone transduction in primate evolution.

Proceedings of the National Academy of Sciences of the United States of America - 18 Mar 2003

Liman Emily R, Innan Hideki

Abstract excerpt

The vomeronasal organ (VNO) detects pheromones in many vertebrate species but is likely to be vestigial in humans. TRPC2(TRP2), a gene that is essential for VNO function in the mouse, is a pseudogene in humans. Because TRPC2 is expressed only in the VNO, the loss of selective pressure on this gene can serve as a molecular marker for the time at which the VNO became vestigial. By analyzing sequence data from the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium Channels
Share to Hominidae
Share to Ion Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pheromones

Share to Primates

Share to Selection, Genetic

Share to TRPC Cation Channels

Share to TRPM Cation Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 12631698
DOI: 10.1073/pnas.0636123100
PMCID: PMC152292

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Relaxed selective pressure on an essential component of pheromone transduction in primate evolution.PMID 12631698Read ↗

Extreme variability among mammalian V1R gene families.Semantic proximity Read ↗

Dramatic variation of the vomeronasal pheromone receptor gene repertoire among five orders of placental and marsupial mammals.Semantic proximity Read ↗

An Evolutionary Novelty in TRPV1 Functional Regulation: Characterization of a Dominant-Negative Isoform Exclusive to Catarrhine PrimatesSemantic proximity Read ↗

Divergent V1R repertoires in five species: Amplification in rodents, decimation in primates, and a surprisingly small repertoire in dogs.Semantic proximity Read ↗

TRPC2.Semantic proximity Read ↗

Sensory rewiring in an echolocator: genome-wide modification of retinogenic and auditory genes in the bat Myotis davidii.Semantic proximity Read ↗

Loss of sex discrimination and male-male aggression in mice deficient for TRP2.Semantic proximity Read ↗

Relaxation of selective constraint and loss of function in the evolution of human bitter taste receptor genes.Semantic proximity Read ↗

The evolution of pheromonal communication.Semantic proximity Read ↗

Adaptive diversification of vomeronasal receptor 1 genes in rodents.Semantic proximity Read ↗

Selective pressures on the olfactory receptor repertoire since the human-chimpanzee divergence.Semantic proximity Read ↗

Frequent loss and alteration of the MOXD2 gene in catarrhines and whales: a possible connection with the evolution of olfaction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.