Article
Assessment of the genotoxic potential of ISIS 2302: a phosphorothioate oligodeoxynucleotide.
Mutagenesis - 1 May 2002
Henry Scott P, Monteith D K, Matson J E, Mathison B H, Loveday K S, Winegar R A, Matson J E, Lee P S, Riccio E S, Bakke J P, Levin A A
Abstract excerpt
ISIS 2302, a phosphorothioate oligodeoxynucleotide with antisense activity against human ICAM-1 mRNA, was evaluated in a battery of tests to assess genotoxic potential. There was no evidence of genotoxicity in three in vitro studies performed: (i) a bacterial reverse mutation test; (ii) a chromosomal aberration test in Chinese hamster ovary cells; (iii) a mammalian cell gene mutation assay in L5187Y cells....
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